研究成果発表実績

雑誌論文

平成25年度:


          (査読あり)
1) Matsuura K, Haraguchi Y, Shimizu T, Okano T, Cell sheet transplantation for heart tissue repair, J Control Release, 169(3), 336-340 (2013).
2) Sekiya S, Shimizu T, Okano T, Vascularization in 3D tissue using cell sheet technology, Regen Med, 8(3), 371-377 (2013).
3) Haraguchi Y, Matsuura K, Shimizu T, Yamato M, Okano T, Simple suspension culture system of human iPS cells maintaining their pluripotency for cardiac cell sheet engineering, J Tissue Eng Regen Med. 2013 Jun 3. doi: 10.1002/term.1761. [Epub ahead of print]
4) Kubo H, Shioyama T, Oura M, Suzuki A, Ogawa T, Makino H, Takeda S, Kino-Oka M, Shimizu T, Okano T, Yamamori S, Development of automated 3-dimensional tissue fabrication system Tissue factory - Automated cell isolation from tissue for regenerative medicine, Conf Proc IEEE Eng Med Biol Soc. 2013 Jul; 58-61.
5) Nagase K, Hatakeyama Y, Shimizu T, Matsuura K, Yamato M, Takeda N, Okano T, Hydrophobized thermoresponsive copolymer brushes for cell separation by multistep temperature change, Biomacromolecules, 14(10): 3423-3433 (2013).
6) Sekine W, Haraguchi Y, Shimizu T, Yamato M, Umezawa A, Okano T, Chondrocyte Differentiation of Human Endometrial Gland-Derived MSCs in Layered Cell Sheets, Scientific World Journal, 2013 Nov 18. doi: 10.1155/2013/359109.
7) Kikuchi T, Shimizu T, Wada M, Yamato M, Okano T, Automatic fabrication of 3-dimensional tissues using cell sheet manipulator technique, Biomaterials, 2013 Dec 23. doi: 10.1016/j.biomaterials.2013.12.014. [Epub ahead of print]
8) Takeuchi R, Kuruma Y, Sekine H, Dobashi I, Yamato M, Umezu M, Shimizu T, Okano T, In vivo vascularization of cell sheets provided better long-term tissue survival than injection of cell suspension, J Tissue Eng Regen Med. 2014 Jan 28. doi: 10.1002/term.1854. [Epub ahead of print]


          (査読なし)
1) 松浦勝久, 清水達也, 岡野光夫: 細胞シート工学とiPS細胞技術の融合による心筋再生医療の創生, 東京都臨床工学技士会会誌, 24(1):49-54 (2013).
2) 関根秀一: 細胞シート工学による心血管組織の構築, 今日の移植, 26(4):325 (2013).
3) 関根佳織, 清水達也: 組織工学を用いた心筋再生医療, 月刊循環器, 3(9):54-63 (2013).
4) Egami M, Haraguchi Y, Shimizu T, Yamato M, Okano T, Latest status of the clinical and industrial applications of cell sheet engineering and regenerative medicine, Arch Pharm Res, 37(1):96-106 (2014).
5) 紀ノ岡正博: ヒト細胞培養のための基材設計と細胞シートの活用,超精密,19:52-57 (2013).
6) 紀ノ岡正博: 細胞加工施設(Cell Processing Facility: CPF),再生医療,12(4):394-395 (2013).
7) Matsuura K, Shimizu T, Okano T, Toward the development of bioengineered human three-dimensional vascularized cardiac tissue using cell sheet technology, Int Heart, 55(1):1-7 (2014).
8) 水谷 学, 紀ノ岡正博:再生医療製品の改正薬事法における製造承認と再生医療新法における製造,PHARMSTAGE 13(12): 30-35 (2014).
9) 関根秀一, 清水達也, 岡野光夫:血管網付与技術による3次元心筋組織の構築,最新医学 69(877): 677 (2014).
10) 松浦勝久:iPS細胞大量培養技術開発,最新医学 69(877): 714 (2014).




平成24年度:


          (査読あり)
1) Matsuura K, Wada M, Shimizu T, Haraguchi Y, Sato F, Sugiyama K, Konishi K, Shiba Y, Ichikawa H, Tachibana A, Ikeda U, Yamato M, Hagiwara N, Okano T, Creation of human cardiac cell sheets using pluripotent stem cells, Biochem Biophys Res Commun (Epub 2012 Jul 25)
2) Forte G, Pagliari S, Ebara M, Uto K, Tam JK, Romanazzo S, Escobedo-Lucea C, Romano E, Di Nardo P, Traversa E, Aoyagi T, Substrate Stiffness Modulates Gene Expression and Phenotype in Neonatal Cardiomyocytes in vitro, Tissue Engineering Part A, 18, 1837-1848 (2012). (Epub 2012 Jun 12)
3) K. Uto, T. Muroya, M. Okamoto, H. Tanaka, T. Murase, M. Ebara, T. Aoyagi, Design of super-elastic biodegradable scaffolds with longitudinally-oriented microchannels and optimization of the channel size for schwann cells migration, Science and Technology of Advanced Materials, in press.
4) J. K. V. Tam, K. Uto, M. Ebara, S. Pagliari, G. Forte, T Aoyagi, Mesenchymal stem cell adhesion but not plasticity is affected by high substrate stiffness, Science and Technology of Advanced Materials, in press.
5) N. Idota, M. Ebara, Y. Kotsuchibashi, R. Narain, T. Aoyagi, Novel temperature-responsive polymer brushes with carbohydrate residues facilitate selective adhesion and collection of hepatocytes, Science and Technology of Advanced Materials, in press.
6) Shioyama T, Haraguchi Y, Muragaki Y, Shimizu T, Okano T, New isolation system for collecting living cells from tissue, J Biosci Bioeng, 115, 100-103 (2013). (Epub 2012 Oct 10)
7) Kino-oka M, Kim J, Kurisaka K, Kim MH, Preferential growth of skeletal myoblasts and fibroblasts in co-culture on a dendrimer-immobilized surface, J Biosci Bioeng, 115, 96-99 (2013). (Epub 2012 Sep 14)
8) Nagamori E, Ngo TX, Takezawa Y, Saito A, Sawa Y, Shimizu T, Okano T, Taya M, Kino-oka M, Network formation through active migration of human vascular endothelial cells in a multilayered skeletal myoblast sheet, Biomaterials, 34, 662-668 (2013). (Epub 2012 Oct 30)
9) Matsuura K, Wada M, Konishi K, Sato M, Iwamoto U, Sato Y, Tachibana A, Kikuchi T, Iwamiya T, Shimizu T, Yamashita JK, Yamato M, Hagiwara N, Okano T, Fabrication of mouse embryonic stem cell-derived layered cardiac cell sheets using a bioreactor culture system, PLoS One, 7, e52176. (Epub 2012 Dec 20)
10) Sekine H, Shimizu T, Sakaguchi K, Dobashi I, Wada M, Yamato M, Kobayashi E, Umezu M, Okano T, In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels, Nat Commun, 4, 1399 (2013).
11) Sakaguchi K, Shimizu T, Horaguchi S, Sekine H, Yamato M, Umezu M, Okano T, In vitro engineering of vascularized tissue surrogates, Sci Rep, 3, 1316 (2013).
12) Sekiya S, Shimizu T, Yamato M, Okano T, Hormone supplying renal cell sheet in vivo produced by tissue engineering technology, Biores Open Access, 2(1), 12-9 (2013).
13) Ngo TX, Nagamori E, Kikuchi T, Shimizu T, Okano T, Taya M, Kino-Oka M, Endothelial cell behavior inside myoblast sheets with different thickness, Biotechnol Lett. 2013 Mar 21. (Epub ahead of print)

          (査読なし)
1) 関根秀一, 清水達也: 細胞シート工学による心筋構造構築, 循環器内科, 71(4), 369 (2012).
2) 関根秀一, 清水達也, 岡野光夫: 細胞シート再生治療とその厚い組織・臓器作製に向けた挑戦, 人工臓器, 41, 7-10 (2012).
3) 関根秀一, 清水達也, 岡野光夫: 細胞シート再生治療と三次元組織の作製, リンパ学. 35, 84-88 (2012).
4) 関根秀一, 清水達也, 岡野光夫: 胞シート工学による高度な三次元組織の構築, バイオマテリアル-生体材料, 30, 188-189 (2012).




平成23年度:


          (査読あり)
1) Matsuura K, Masuda S, Haraguchi Y, Yasuda N, Shimizu T, Hagiwara N, Zandstra PW, Okano T, Creation of mouse embryonic stem cell-derived cardiac cell sheets, Biomaterials 32(30): 7355-7362 (2011). (Epub 2011 Jul 31)
2) Sekine H, Shimizu T, Dobashi I, Matsuura K, Hagiwara N, Takahashi M, Kobayashi E, Yamato M, Okano T, Cardiac cell sheet transplantation improves damaged heart function via superior cell survival in comparison with dissociated cell injection, Tissue Eng Part A. 17(23-24): 2973-80 (2011). (Epub 2011 Aug 29)
3) Oura M, Kubo H, Yamamori S, Takeda S, Shimizu T, Okano T, Development of cell culture monitoring system and novel non-contact pH measurement, Conf Proc IEEE Eng. Med. Biol. Soc. Aug;2011: 22-25 (2011).
4) Kino-oka M, Ngo TX, Nagamori E, Takezawa Y, Miyake Y, Sawa Y, Saito A, Shimizu T, Okano T, Taya M, Evaluation of vertical cell fluidity in a multilayered sheet of skeletal myoblasts, J. Biosci. Bioeng., 113(1), 128-31 (2012). (Epub 2011 Oct 20)
5) Sekine H, Shimizu T, Okano T, Myocardial tissue engineering: toward a bioartificial pump, Cell Tissue Res. Epub 2011 Nov 18.
6) Sekine W, Haraguchi Y, Shimizu T, Umezawa A, Okano T, Thickness limitation and cell viability of multi-layered cell sheets and overcoming the diffusion limit by a porous-membrane culture insert, J. Biochips Tissue Chips, 2153-0777-S1-007 (2011).
7) Haraguchi Y, Shimizu T, Sasagawa T, Sekine H, Sakaguchi K, Kikuchi T, Sekine W, Sekiya S,Yamato M, Umezu M, Okano T, Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro, Nature Protocols 7, 850–858 (2012).

          (査読なし)
1) 清水達也: 臓器創生に向けた基盤技術の開発, 医療機器学, 81(6), 430-433 (2011).
2) 紀ノ岡正博, 水谷学: 組織ファクトリー産業化への課題, 医療機器学, 81(6), 434-438 (2011).
3) 久保寛嗣: 自動初代培養装置が開く再生医療, 医療機器学, 81(6), 439-445 (2011).
4) 菊地鉄太郎, 和田昌憲, 水谷学: 細胞シート自動積層化装置が開く再生医療: 医療機器学, 81(6), 452-458 (2011).
5) 水谷学, 紀ノ岡正博, 清水達也, 岡野光夫: 細胞シート再生治療を支援する自動培養三次元化システム, JJCLA(日本臨床検査自動化学会), 37(2), 61-65 (2012).
6) 水谷学、清水達也、岡野光夫: 再生医療産業化と世界普及:組織・臓器ファクトリーの創生, TEST 22(1), 4-6 (2012).




平成22年度:


1) 浦栃信吾,大野翔太,紀ノ岡正博,田谷正仁: 移植用組織生産における細胞挙動シミュレーション、ケミカルエンジニアリング, 55(11), 814-818 (2010).
2) Sekiya S, Muraoka M, Sasagawa T, Shimizu T, Yamato M, Okano T, Microvasc. Res. 80(3): 549-51 (2010). (Epub 2010 Aug 6)
3) Sekiya S, Shimizu T, Yamato M, Okano T, "Deep-media culture condition" promoted lumen formation of endothelial cells within engineered three-dimensional tissues in vitro, J Artif Organs. 14(1):43-51 (2011). (Epub 2011 Feb 2)




平成21年度: なし






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