o-factory

   ORGAN FACTORY

Establishment of organ factory using cell sheet engineering
   The technology development for scaling-up tissue (organ engineering) has been requested to treat more severe diseases and to replace donor organ implantation. Mass culture of ES/iPS cells, sorting of target cells and sufficient vascularization within multiple layers of cell sheets are key technologies to be broken through. We challenge to fabricate functionally thick tissues for future transplantation of bioengineered organs.
Prof. OKANO
Core Researcher
Prof. Teruo Okano, Ph.D


Schematic diagram of our destination


aim_o-factory




NEWS

2013/ 2/23 Paper on a vascularization method of layered cell sheets has been published in Scientific Reports.
Sakaguchi K, Shimizu T, Horaguchi S, Sekine H,Yamato M, Umezu M, Okano T. " In Vitro Engineering of Vascularized Tissue Surrogates." Scientific Reports 3, Article number: 1316, 2013.
2013/ 1/31 Paper on a vascularization method of layered cell sheets has been published in Nature Communications.
Sekine H, Shimizu T, Sakaguchi K, Dobashi Y, Wada M,Yamato M, Kobayashi E, Umezu M, Okano T. "In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels." Nature Communications 4, Article number: 1399, 2013.
2012/ 4/ 9 Paper on the manipulation methods of layered cell sheets has been published in Nature Protocols.
Haraguchi Y, Shimizu T, Sasagawa T, Sekine H, Sakaguchi K, Kikuchi T, Sekine W, Sekiya S,Yamato M, Umezu M, Okano T. "Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro." Nature Protocols 7, 850–858 (2012).
2011/ 6/27 English page started.

NEWS_END


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What's Cell Sheet Engineering?

Cell Sheet Engineering
"TISSUE FACTORY"

T-FACTORY
"ORGAN FACTORY"

O-TACTORY

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