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10]\u306b\u304a\u3044\u3066\u3001\u5f7c\u3089\u306e\u8840\u4e2d\u9178\u7d20\u98fd\u548c\u5ea6\u306f\u6a19\u9ad8\u304c\u4f4e\u3044\u5730\u57df\u3067\u66ae\u3089\u3059\u300c\u4f4e\u5730\u4eba\u300d\u304c\u9ad8\u5730\u306b\u3044\u308b\u5834\u5408\u3068\u540c\u7a0b\u5ea6\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u308c\u306b\u3082\u95a2\u308f\u3089\u305a\u9ad8\u3044\u904b\u52d5\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u767a\u63ee\u3067\u304d\u308b\u7406\u7531\u3068\u3057\u3066\u3001\u5f7c\u3089\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304cATP\u3092\u751f\u6210\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u5f97\u308b\u969b\u3001\u300c\u4f4e\u5730\u4eba\u300d\u306b\u6bd4\u3079\u3066\u9178\u7d20\u3092\u3088\u308a\u52b9\u7387\u7684\u306b\u4f7f\u7528\u3067\u304d\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b[10]\u3002\u672c\u7a3f\u3067\u306f\u4ee5\u5f8c\u3001\u30b7\u30a7\u30eb\u30d1\u65cf\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u300c\u4f4e\u9178\u7d20\u8010\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u300d\u3068\u3059\u308b\u3002<\/p><p>\u3000\u672c\u7814\u7a76\u3067\u306f\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u60a3\u8005\u307e\u305f\u9ad8\u30ea\u30b9\u30af\u8005\u306e\u5fc3\u7b4b\u7d30\u80de\u306b\u5bfe\u3057\u3001\u4f4e\u9178\u7d20\u8010\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u79fb\u690d\u3059\u308b\u3053\u3068\u3067\u865a\u8840\u72b6\u614b\u3078\u306e\u8010\u6027\u3092\u4ed8\u4e0e\u3059\u308b\u3053\u3068\u3092\u8003\u6848\u3057\u305f\u3002<\/p><h5><strong>3.2. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u79fb\u690d\u65b9\u6cd5<\/strong><\/h5><p>\u3000\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u5973\u6027\u306e\u5375\u5b50\u306b\u6b63\u5e38\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5c0e\u5165\u3059\u308b\u751f\u6b96\u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7f6e\u63db\u306f\u3059\u3067\u306b\u5b9f\u7528\u6bb5\u968e\u306b\u3042\u308b[11]\u3002\u3057\u304b\u3057\u3001\u4f53\u7d30\u80de\u3078\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u79fb\u690d\u306fin vitro\u306e\u7814\u7a76[12]\u304c\u307b\u3068\u3093\u3069\u3067\u3001\u81e8\u5e8a\u7814\u7a76[13]\u306f\u307e\u3060\u5c11\u6570\u3067\u3042\u308b\u3002\u751f\u6b96\u7d30\u80de\u3068\u306f\u7570\u306a\u308a\u3001\u591a\u304f\u306e\u7d30\u80de\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5c4a\u3051\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3053\u3068\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/p><p>\u3000\u56f31. 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\u306b\u672c\u7814\u7a76\u306e\u6a5f\u80fd\u6027\u4eba\u5de5\u5fae\u751f\u7269\u306e\u6982\u8981\u3092\u793a\u3059\u3002\u3053\u306e\u6a5f\u80fd\u6027\u4eba\u5de5\u5fae\u751f\u7269\u306f\u3001\u771f\u6838\u751f\u7269\u306e\u7d30\u80de\u5c0f\u5668\u5b98\u3092\u5099\u3048\u308b\u3053\u3068\u3067\u5206\u88c2\u3068\u540c\u6642\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5897\u3084\u3059\u3053\u3068\u304c\u3067\u304d\u3001\u30a6\u30a4\u30eb\u30b9\u69d8\u306e\u5916\u819c\u3092\u5099\u3048\u308b\u3053\u3068\u3067\u7279\u5b9a\u306e\u7d44\u7e54\u306b\u4fb5\u5165\u3067\u304d\u308b\u3088\u3046\u306a\u3082\u306e\u3092\u8003\u3048\u3066\u3044\u308b\u3002<\/p><div class=\"fig\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter  wp-image-517\" src=\"http:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-content\/uploads\/2024\/09\/\u56f31-\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u79fb\u690d\u6cd5.png\" alt=\"\" width=\"717\" height=\"523\" \/><div class=\"caption\" style=\"text-align: center;\">\u56f31 \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u79fb\u690d\u6cd5<\/div><\/div><p>&nbsp;<\/p><div class=\"fig\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter  wp-image-518\" src=\"http:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-content\/uploads\/2024\/09\/\u56f32-\u672c\u63d0\u6848\u306e\u6a5f\u80fd\u6027\u4eba\u53e3\u5fae\u751f\u7269.png\" alt=\"\" width=\"513\" height=\"393\" \/><div class=\"caption\" style=\"text-align: center;\">\u56f32 \u672c\u63d0\u6848\u306e\u6a5f\u80fd\u6027\u4eba\u53e3\u5fae\u751f\u7269<\/div><\/div><h5><strong>3.3. \u5fc3\u7b4b\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u30c7\u30ea\u30d0\u30ea\u30fc\u3059\u308b\u65b9\u6cd5<\/strong><\/h5><p>\u3000\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u7d30\u80de\u819c\u306b\u5b58\u5728\u3059\u308b\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u611f\u67d3\u3059\u308b\u30021976\u5e74\u3001 Lonberg-Holm\u3089\u304c\u3001\u7570\u306a\u308b\u30a6\u30a4\u30eb\u30b9\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u30b3\u30af\u30b5\u30c4\u30ad\u30fc\u30a6\u30a4\u30eb\u30b9B\u578b\u3068\u3001\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u306e2\u578b\u30685\u578b\u304c\u3001\u5171\u901a\u306e\u819c\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f[16]\u3002\u3053\u306e\u5171\u901a\u819c\u53d7\u5bb9\u4f53\u306fCoxsackievirus and Adenovirus Receptor\uff08CAR\uff09\u3068\u547d\u540d\u3055\u308c\u3001\u591a\u304f\u306e\u7814\u7a76\u8005\u306b\u3088\u3063\u3066\u305d\u306e\u751f\u7269\u5b66\u7684\u6a5f\u80fd\u306e\u89e3\u6790\u304c\u9032\u3081\u3089\u308c\u3066\u304d\u305f[17]\u3002<\/p><p>\u3000\u30b3\u30af\u30b5\u30c4\u30ad\u30fc\u30a6\u30a4\u30eb\u30b9\u3068\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u306f\u30ab\u30d7\u30b7\u30c9\u306e\u5916\u5074\u306b\u3042\u308b\u30d5\u30a1\u30a4\u30d0\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4ecb\u3057\u3066\u3001\u5bbf\u4e3b\u7d30\u80de\u306b\u5b58\u5728\u3059\u308b\u53d7\u5bb9\u4f53CAR\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u7d30\u80de\u8868\u9762\u306b\u5438\u7740\u3057\u3066\u7d30\u80de\u5185\u90e8\u306b\u4fb5\u5165\u3059\u308b\u3002CAR\u306f\u5fc3\u81d3\u3084\u8133\u306a\u3069\u3044\u304f\u3064\u304b\u306e\u7d44\u7e54\u3067\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u5fc3\u7b4b\u708e\u306a\u3069\u306e\u75c5\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p><p>\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u56f32. \u306b\u793a\u3057\u305f\u3088\u3046\u306a\u30b3\u30af\u30b5\u30c4\u30ad\u30fc\u30a6\u30a4\u30eb\u30b9B\u578b\u69d8\u5916\u819c\u3092\u6301\u3064\u4eba\u5de5\u5fae\u751f\u7269\u3092\u9759\u8108\u6ce8\u5c04\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u4f4e\u4fb5\u8972\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5fc3\u7b4b\u306b\u30c7\u30ea\u30d0\u30ea\u30fc\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u305f\u3002\u56f33. \u306b\u672c\u7814\u7a76\u306e\u4eba\u5de5\u5fae\u751f\u7269\u304c\u7d30\u80de\u5185\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5c4a\u3051\u308b\u307e\u3067\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u793a\u3059\u3002\u4eba\u5de5\u5fae\u751f\u7269\u306f\u5916\u5074\u306b\u3042\u308b\u30d5\u30a1\u30a4\u30d0\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4ecb\u3057\u3066\u3001\u5bbf\u4e3b\u7d30\u80de\u306b\u5b58\u5728\u3059\u308b\u53d7\u5bb9\u4f53CAR\u3068\u7d50\u5408\u3059\u308b\u3002\u305d\u306e\u5f8c\u3001\u30d5\u30a1\u30a4\u30d0\u30fc\u306e\u6839\u672c\u306e\u30da\u30f3\u30c8\u30f3\u30d9\u30fc\u30b9\u306b\u3042\u308bRGD\u3068\u3044\u3046\u30a2\u30df\u30ce\u9178\u914d\u5217\u304c\u3001\u7d30\u80de\u8868\u9762\u306e\u63a5\u7740\u5206\u5b50\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\u3068\u7d50\u5408\u3057\u3001\u3053\u306e\u8907\u5408\u4f53\u304c\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u3055\u308c\u3066\u7d30\u80de\u5185\u306b\u5165\u308b\u3002\u6b21\u306b\u3001\u30a8\u30f3\u30c9\u30bd\u30fc\u30de\u30eb\u30a8\u30b9\u30b1\u30fc\u30d7\u306b\u3088\u308a\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u819c\u306e\u4e2d\u304b\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u653e\u51fa\u3055\u308c\u3066\u79fb\u690d\u304c\u5b8c\u4e86\u3059\u308b\u3002\u7d30\u80de\u5185\u306b\u6b8b\u3063\u305f\u4eba\u5de5\u5fae\u751f\u7269\u306e\u5916\u819c\u3001\u7d30\u80de\u5c0f\u5668\u5b98\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u308a\u5206\u89e3\u3055\u308c\u308b\u3002<\/p><div class=\"fig\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter  wp-image-519\" src=\"http:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-content\/uploads\/2024\/09\/\u56f33-\u4eba\u53e3\u5fae\u751f\u7269\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\ufffd\u30ea\u30a2\u9001\u9054\u904e\u7a0b.png\" alt=\"\" width=\"444\" height=\"522\" \/><div class=\"caption\" style=\"text-align: center;\">\u56f33 \u4eba\u53e3\u5fae\u751f\u7269\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u9001\u9054\u904e\u7a0b<\/div><\/div><h5><strong>3.4. \u5408\u6210\u751f\u7269\u5b66\u306b\u3088\u308b\u4eba\u5de5\u5fae\u751f\u7269\u306e\u5275\u9020<\/strong><\/h5><p>\u3000\u5408\u6210\u751f\u7269\u5b66\uff08Synthetic Biology\uff09\u306f\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u9818\u57df\u306b\u304a\u3051\u308b\u4e16\u754c\u7684\u306a\u7814\u7a76\u30c8\u30ec\u30f3\u30c9\u306e\u4e00\u3064\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u300c\u751f\u547d\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u300d\u3067\u3042\u308b\u30b2\u30ce\u30e0\u306e\u7db2\u7f85\u7684\u89e3\u6790\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f\u3053\u3068\u306b\u3088\u308a\u3001\u751f\u7269\u306e\u69cb\u6210\u8981\u7d20\u3068\u305d\u306e\u6a5f\u80fd\u3001\u304a\u3088\u3073\u30b2\u30ce\u30e0\u60c5\u5831\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u751f\u7269\u3092\u4eba\u5de5\u7684\u306b\u300c\u5275\u308b\u300d\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u5b9f\u969b\u306b\u30012010\u5e74\u306b\u306fCraig Venter\u3089\u304c\u3001\u7d30\u83cc\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u306e\u5168\u30b2\u30ce\u30e0\u3092\u5316\u5b66\u5408\u6210\u3057\u3001\u305d\u306e\u5408\u6210\u30b2\u30ce\u30e0\u3092\u8fd1\u7e01\u7a2e\u306e\u5225\u306e\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u306b\u79fb\u690d\u3057\u305f\u3068\u3053\u308d\u3001\u5408\u6210\u30b2\u30ce\u30e0\u306e\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308a\u3001\u751f\u304d\u305f\u7d30\u83cc\u3068\u3057\u3066\u5206\u88c2\u3084\u5897\u6b96\u3082\u59cb\u3081\u305f\u3068\u3044\u3046\u7814\u7a76\u3092\u767a\u8868\u3057\u3001\u4e16\u754c\u306e\u6ce8\u76ee\u3092\u96c6\u3081\u305f[18]\u3002<\/p><p>\u3000\u4eca\u5f8c\u306e\u5408\u6210\u751f\u7269\u5b66\u306e\u767a\u5c55\u306b\u3088\u308a\u3001\u751f\u547d\u6a5f\u80fd\u3092\u4eba\u5de5\u7684\u306b\u30c7\u30b6\u30a4\u30f3\u30fb\u69cb\u7bc9\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u672c\u7814\u7a76\u306e\u6a5f\u80fd\u6027\u4eba\u5de5\u5fae\u751f\u7269\u304c\u5b9f\u73fe\u3059\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002<\/p><h5><strong>3.5. \u6cbb\u7642\u306e\u5168\u4f53\u50cf<\/strong><\/h5><p>\u3000\u6700\u5f8c\u306b\u6cbb\u7642\u306e\u5168\u4f53\u50cf\u306b\u3064\u3044\u3066\u8aac\u660e\u3059\u308b\u3002 \u307e\u305a\u3001\u4f4e\u9178\u7d20\u8010\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5c0e\u5165\u3057\u305f\u6a5f\u80fd\u6027\u4eba\u5de5\u5fae\u751f\u7269\u3092\u57f9\u990a\u3059\u308b\u3002\u4eba\u5de5\u5fae\u751f\u7269\u306e\u5206\u88c2\u3068\u3068\u3082\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3082\u534a\u81ea\u52d5\u5897\u6b96\u3059\u308b\u3002\u60a3\u8005\u306b\u57f9\u990a\u3057\u305f\u4eba\u5de5\u5fae\u751f\u7269\u3092\u9759\u8108\u6ce8\u5c04\u3059\u308b\u3002\u4eba\u5de5\u5fae\u751f\u7269\u306fCAR\u3092\u4ecb\u3057\u3066\u5fc3\u7b4b\u7d30\u80de\u8868\u9762\u306b\u5438\u7740\u3057\u3001\u7d30\u80de\u5185\u306b\u4fb5\u5165\u3059\u308b\u3002\u7d30\u80de\u5185\u306b\u4fb5\u5165\u3057\u305f\u4eba\u5de5\u5fae\u751f\u7269\u304b\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u653e\u51fa\u3055\u308c\u3001\u79fb\u690d\u304c\u5b8c\u4e86\u3059\u308b\u3002\u6700\u7d42\u7684\u306b\u3001\u7d30\u80de\u5185\u306b\u79fb\u690d\u3055\u308c\u305f\u4f4e\u9178\u7d20\u8010\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u3088\u308a\u5fc3\u7b4b\u7d30\u80de\u304c\u865a\u8840\u72b6\u614b\u306b\u5f37\u304f\u306a\u308a\u3001\u5fc3\u7b4b\u6897\u585e\u306e\u767a\u751f\u304c\u6291\u5236\u3055\u308c\u308b\u3002<\/p><h5><strong>4. \u8ab2\u984c\u3068\u5c55\u671b<\/strong><\/h5><h5><strong>4.1. \u4eba\u5de5\u5fae\u751f\u7269\u306e\u75c5\u539f\u6027<\/strong><\/h5><p>\u3000\u4f53\u5185\u3067\u4eba\u5de5\u5fae\u751f\u7269\u304c\u5897\u6b96\u3057\u305f\u5834\u5408\u3001\u6557\u8840\u75c7\u306a\u3069\u91cd\u7be4\u306a\u75c7\u72b6\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u9ad8\u6e29\u83cc\u3084\u4f4e\u6e29\u83cc\u306e\u3088\u3046\u306b\u30d2\u30c8\u306e\u4f53\u6e29\u3068\u306f\u7570\u306a\u308b\u6e29\u5ea6\u3067\u5897\u6b96\u3059\u308b\u6027\u8cea\u3092\u4eba\u5de5\u5fae\u751f\u7269\u306b\u4ed8\u4e0e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u4f53\u5185\u3067\u306e\u5897\u6b96\u3092\u4e0d\u53ef\u80fd\u3068\u3059\u308b\u65b9\u6cd5\u304c\u8003\u3048\u3089\u308c\u308b\u3002\u307e\u305f\u3001\u7279\u5b9a\u306e\u85ac\u5264\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u9ad8\u3081\u3066\u304a\u304f\u3053\u3068\u3067\u8fc5\u901f\u306b\u4f53\u5185\u304b\u3089\u6392\u9664\u3067\u304d\u308b\u3088\u3046\u306b\u3059\u308b\u65b9\u6cd5\u3082\u8003\u3048\u3089\u308c\u308b\u3002<\/p><h5><strong>4.2. \u30c7\u30ea\u30d0\u30ea\u30fc\u306e\u7cbe\u5ea6<\/strong><\/h5><p>\u3000\u672c\u63d0\u6848\u306b\u304a\u3044\u3066\u4eba\u5de5\u5fae\u751f\u7269\u304c\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u306e\u306f\u819c\u53d7\u5bb9\u4f53CAR\u3067\u3042\u308b\u3002CAR\u306f\u5fc3\u7b4b\u7d30\u80de\u4ee5\u5916\u306b\u8133\u3084\u4e0a\u76ae\u7d30\u80de\u306e\u4e00\u90e8\u306b\u3082\u767a\u73fe\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u5916\u306e\u7d44\u7e54\u3078\u3082\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u30c7\u30ea\u30d0\u30ea\u30fc\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002CAR\u3078\u306e\u7d50\u5408\u306b\u969b\u3057\u3001\u5fc3\u7b4b\u7d30\u80de\u306b\u9ad8\u5ea6\u306b\u767a\u73fe\u3059\u308b\u819c\u8cab\u901a\u30bb\u30ea\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3001\u30b3\u30ea\u30f3[19]\u306b\u3088\u308b\u30d5\u30a1\u30a4\u30d0\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u958b\u88c2\u3092\u5fc5\u8981\u3068\u3059\u308b\u3088\u3046\u306b\u4eba\u5de5\u5fae\u751f\u7269\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5fc3\u7b4b\u7d30\u80de\u306b\u9650\u5b9a\u7684\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u30c7\u30ea\u30d0\u30ea\u30fc\u3055\u305b\u308b\u65b9\u6cd5\u304c\u8003\u3048\u3089\u308c\u308b\u3002<\/p><h5><strong>4.3. \u5c55\u671b<\/strong><\/h5><p>\u3000\u4eba\u5de5\u5fae\u751f\u7269\u306e\u30d9\u30af\u30bf\u30fc\u3067\u3042\u308b\u30d5\u30a1\u30a4\u30d0\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5909\u66f4\u3059\u308b\u3053\u3068\u3067\u3001\u865a\u8840\u306b\u3088\u3063\u3066\u5c3f\u7d30\u7ba1\u4e0a\u76ae\u7d30\u80de\u306e\u5265\u96e2\u8131\u843d\u304c\u8d77\u3053\u308b\u865a\u8840\u6027\u5c3f\u7d30\u7ba1\u9593\u8cea\u6027\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u306b\u9069\u5fdc\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u307e\u305f\u3001T\u7d30\u80de\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6d3b\u6027\u5316\u306b\u3088\u308a\u304c\u3093\u306b\u5bfe\u3059\u308b\u514d\u75ab\u5fdc\u7b54\u306e\u52b9\u679c\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b[20]\u3053\u3068\u304b\u3089\u3001\u304c\u3093\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u3082\u671f\u5f85\u3067\u304d\u308b\u3002\u5bfe\u8c61\u304c\u514d\u75ab\u7d30\u80de\u306e\u5834\u5408\u3001\u8caa\u98df\u4f5c\u7528\u304c\u3042\u308b\u305f\u3081\u3088\u308a\u7c21\u5358\u306b\u30c7\u30ea\u30d0\u30ea\u30fc\u304c\u53ef\u80fd\u3067\u3042\u308b\u3002<\/p><h5><strong>5. \u7d50\u8ad6<\/strong><\/h5><p>\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u8d85\u9ad8\u5730\u3067\u751f\u6d3b\u3059\u308b\u4eba\u3005\u306e\u6301\u3064\u4f4e\u9178\u7d20\u8010\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u3001\u771f\u6838\u751f\u7269\u306e\u7d30\u80de\u5c0f\u5668\u5b98\u3068\u30b3\u30af\u30b5\u30c4\u30ad\u30fc\u30a6\u30a4\u30eb\u30b9B\u578b\u69d8\u5916\u819c\u3092\u4f75\u305b\u6301\u3064\u6a5f\u80fd\u6027\u4eba\u5de5\u5fae\u751f\u7269\u306b\u3088\u3063\u3066\u5fc3\u7b4b\u7d30\u80de\u306b\u79fb\u690d\u3057\u3001\u4f4e\u9178\u7d20\u8010\u6027\u3092\u4ed8\u4e0e\u3059\u308b\u65b9\u6cd5\u3092\u8003\u6848\u3057\u305f\u3002\u5fc3\u7b4b\u306b\u4f4e\u9178\u7d20\u8010\u6027\u3092\u6301\u305f\u305b\u308b\u3053\u3068\u3067\u3001\u865a\u8840\u306b\u3088\u308b\u7d30\u80de\u306e\u58ca\u6b7b\u3092\u9632\u304e\u3001\u5fc3\u7b4b\u6897\u585e\u3092\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u3092\u898b\u8fbc\u3093\u3067\u3044\u308b\u3002\u307e\u305f\u3001\u4fb5\u8972\u6027\u304c\u4f4e\u3044\u6a5f\u80fd\u6027\u4eba\u5de5\u5fae\u751f\u7269\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u79fb\u690d\u306b\u3088\u308a\u3001\u5fc3\u7b4b\u6897\u585e\u3092\u4e00\u5ea6\u3082\u767a\u75c7\u3057\u305f\u3053\u3068\u304c\u306a\u3044\u9ad8\u30ea\u30b9\u30af\u8005\u306b\u5bfe\u3059\u308b\u4e88\u9632\u7684\u4ecb\u5165\u306b\u3082\u9069\u7528\u3067\u304d\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u308b\u3002<\/p><h5><strong>6. \u53c2\u8003\u6587\u732e<\/strong><\/h5><p>[1] \u539a\u751f\u52b4\u50cd\u7701: \u4ee4\u548c2\u5e74(2020)\u4eba\u53e3\u52d5\u614b\u7d71\u8a08(\u78ba\u5b9a\u6570)\u306e\u6982\u6cc1.<\/p><p>[2] 2011\u5e74\u5ea6\u5408\u540c\u7814\u7a76\u73ed: \u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u4e00\u6b21\u4e88\u9632\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3. 2012.<\/p><p>[3] F. Wang et al.: Global Burden of Ischemic Heart Disease and Attributable Risk Factors, 1990\u20132017: A Secondary Analysis Based on the Global Burden of Disease Study 2017. Clin Epidemiol, vol. 13, pp. 859\u2013870, Sep. 2021.<\/p><p>[4] <a href=\"https:\/\/www.ncvc.go.jp\/hospital\/section\/cvm\/coronary\/pro-12\/\">https:\/\/www.ncvc.go.jp\/hospital\/section\/cvm\/coronary\/pro-12\/<\/a> (2022\u5e747\u670818\u65e5)<\/p><p>[5] \u4f0a\u85e4\u6d69, \u5c71\u4e0b\u6b66\u5fd7 (\u7de8): \u5faa\u74b0\u5668\u75be\u60a3\u6700\u65b0\u306e\u6cbb\u76422020-2021. \u5357\u6c5f\u5802, 2020.<\/p><p>[6] M. Ishihara et al., \u201cLong-Term Outcomes of Non-ST-Elevation Myocardial Infarction Without Creatine Kinase Elevation \u2015 The J-MINUET Study \u2015,\u201d Circulation Journal, vol. 81, no. 7, pp. 958\u2013965, 2017.<\/p><p>[7] \u65e5\u672c\u5fc3\u81d3\u79fb\u690d\u7814\u7a76\u4f1a: \u65e5\u672c\u306b\u304a\u3051\u308b\u5fc3\u81d3\u79fb\u690d\u5831\u544a. 2021.<\/p><p>[8] \u65e5\u672c\u5faa\u74b0\u5668\u5b66\u4f1a: \u6025\u6027\uff65\u6162\u6027\u5fc3\u4e0d\u5168\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3 (2017\u5e74\u6539\u8a02\u7248). 2018.<\/p><p>[9] \u9577\u5dba\u4fe1\u592b: \u30c1\u30d9\u30c3\u30c8\u9ad8\u5730\u306b\u304a\u3051\u308b\u8840\u4e2d\u9178\u7d20\u98fd\u548c\u5ea6\u306b\u3064\u3044\u3066 \uff5e\u65e5\u672c\u4eba\u65c5\u884c\u8005\u304a\u3088\u3073\u30c1\u30d9\u30c3\u30c8\u4eba\u306e\u8208\u5473\u6df1\u3044\u6e2c\u5b9a\u7d50\u679c\uff5e. \u6c96\u7e04\u533b\u5831, Vol. 47, No. 10, 2011.<\/p><p>[10] J. A. 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Sig Transduct Target Ther, vol. 6, no. 1, pp. 1\u201318, Feb. 2021.<\/p><p>[15] \u8cb4\u5f18\u67f4\u7530, \u7d17\u5b63\u5c71\u4e0b, \u85ab\u52a0\u85e4, \u5584\u6d69\u592a\u7530: \u30c0\u30e1\u30fc\u30b8\u306e\u5c11\u306a\u3044\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5358\u96e2\u6cd5. \u751f\u7269\u7269\u7406, vol. 56, no. 2, pp. 112\u2013115, 2016.<\/p><p>[16] K. Lonberg-Holm et al.: Unrelated animal viruses share receptors. Nature, vol. 259, no. 5545, pp. 679\u2013681, Feb. 1976.<\/p><p>[17] V. G. Khurana and F. B. Meyer: Translational Paradigms in Cerebrovascular Gene Transfer. J Cereb Blood Flow Metab, vol. 23, no. 11, pp. 1251\u20131262, Nov. 2003.<\/p><p>[18] <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.1190719\">https:\/\/www.science.org\/doi\/10.1126\/science.1190719<\/a> (2022\u5e747\u670818\u65e5)<\/p><p>[19] J. D. Hooper et al.: Localization of the mosaic transmembrane serine protease corin to heart myocytes. 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Cell Chem Biol, vol. 29, no. 3, pp. 463-475.e6, Mar. 2022.<\/p><hr \/><div class=\"fig\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-520 aligncenter\" src=\"http:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-content\/uploads\/2024\/09\/\u5199\u771f_\u5c0f\u5ddd\u672a\u771f.jpg\" alt=\"\" width=\"330\" height=\"454\" \/><\/div><h5><strong>\u5c0f\u5ddd \u672a\u771f\uff08\u304a\u304c\u308f \u307f\u307e\uff09<\/strong><\/h5><p><strong>\u682a\u5f0f\u4f1a\u793e\u65e5\u7acb\u88fd\u4f5c\u6240 \u7814\u7a76\u958b\u767a\u30b0\u30eb\u30fc\u30d7<\/strong><\/p>","protected":false},"excerpt":{"rendered":"1. \u7dd2\u8a00\u3000\u5fc3\u75be\u60a3\u306f\u3001\u539a\u751f\u52b4\u50cd\u7701\u4ee4\u548c2\u5e74\u4eba\u53e3\u52d5\u614b\u7d71\u8a08[1]\u306b\u304a\u3044\u3066\u3001\u7537\u5973\u3068\u3082\u306b\u6b7b\u56e0\u306e\u7b2c2\u4f4d\u3092\u5360\u3081\u3066\u3044\u308b\u3002\u305d\u306e\u4e2d\u3067\u3082\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u5272\u5408\u306f\u9ad8\u304f\u3001\u5fc3\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u306e42%\u3092\u5360\u3081\u3066\u3044\u308b[2]\u3002\u3055\u3089\u306b\u3001WHO\u306eGDB2017\u8abf\u67fb\u306b [&hellip;]","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"class_list":["post-494","post","type-post","status-publish","hentry","category-6"],"_links":{"self":[{"href":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-json\/wp\/v2\/posts\/494"}],"collection":[{"href":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-json\/wp\/v2\/comments?post=494"}],"version-history":[{"count":0,"href":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-json\/wp\/v2\/posts\/494\/revisions"}],"wp:attachment":[{"href":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-json\/wp\/v2\/media?parent=494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/wp-json\/wp\/v2\/categories?post=494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}