{"id":485,"date":"2024-09-05T16:20:17","date_gmt":"2024-09-05T07:20:17","guid":{"rendered":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/?p=485"},"modified":"2024-09-05T16:49:53","modified_gmt":"2024-09-05T07:49:53","slug":"%e3%83%8f%e3%83%80%e3%82%ab%e3%83%87%e3%83%90%e3%83%8d%e3%82%ba%e3%83%9f%e3%82%92%e6%a8%a1%e5%80%a3%e3%81%97%e3%81%9f%e8%86%b5%e8%87%93%e7%99%8c%e3%81%ae%e6%97%a9%e6%9c%9f%e7%99%ba%e8%a6%8b%e3%83%bb","status":"publish","type":"post","link":"https:\/\/twins.twmu.ac.jp\/SFM\/journal\/archives\/485","title":{"rendered":"\u30cf\u30c0\u30ab\u30c7\u30d0\u30cd\u30ba\u30df\u3092\u6a21\u5023\u3057\u305f\u81b5\u81d3\u764c\u306e\u65e9\u671f\u767a\u898b\u30fb\u6cbb\u7642\u30c7\u30d0\u30a4\u30b9"},"content":{"rendered":"
1. \u7dd2\u8a00<\/strong><\/h5>

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\u56f31.\u00a0 \u81b5\u81d3\u306e\u89e3\u5256 [5]<\/div><\/div>

 <\/p>

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2. \u80cc\u666f<\/strong><\/h5>
2.1. \u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3068\u304c\u3093<\/strong><\/h5>

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2.2. \u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306e\u5206\u5b50\u91cf<\/strong><\/h5>

\u3000HA\u306f\u3001\u4e8c\u7cd6\u5358\u4f4d\u306e\u7e70\u308a\u8fd4\u3057\u3067\u69cb\u6210\u3055\u308c\u308b\u9670\u30a4\u30aa\u30f3\u6027\u306e\u7dda\u72b6\u591a\u7cd6\u3067\u3042\u308a\u3001\u5438\u6e7f\u6027\u304c\u9ad8\u3044\uff1a1g\u306eHA\u306f6L\u306e\u6c34\u3092\u4fdd\u6301\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b10) \u3002HA\u306fHA\u5408\u6210\u9175\u7d20(Hyaluronan Synthase, HAS\uff09\u306b\u3088\u3063\u3066\u5408\u6210\u3055\u308c\u3001\u4e00\u822c\u7684\u306b\u9ad8\u5206\u5b50\u91cf\u30dd\u30ea\u30de\u30fc\uff08HMW-HA\u30011000\u301c6000kDa\u3068\u5b9a\u7fa9\uff09\u3068\u3057\u3066\u7d30\u80de\u8868\u9762\u306b\u76f4\u63a5\u62bc\u3057\u51fa\u3055\u308c\u308b\u3002HMW-HA\u306e\u6bd4\u8f03\u7684\u9ad8\u3044\u7c98\u5f3e\u6027\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u76f8\u4e92\u4f5c\u7528\u306e\u8db3\u5834\u3092\u63d0\u4f9b\u3057\u3001\u81d3\u5668\u3092\u6a5f\u68b0\u7684\u640d\u50b7\u304b\u3089\u4fdd\u8b77\u3059\u308b [10] \u3002HMW-HA\u306f\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u307e\u305f\u306f\u5206\u89e3\u9175\u7d20\u306b\u3088\u308a\u3001\u4f4e\u5206\u5b50\u91cf\u30dd\u30ea\u30de\u30fc\uff08LMW-HA\u3001\u2264250kDa\u3068\u5b9a\u7fa9\uff09\u3078\u65ad\u7247\u5316\u3055\u308c\u308b\u3002\u3053\u306e\u65ad\u7247\u5316\u306f\u3001\u6052\u5e38\u6027\u72b6\u614b\u3067\u306f\u307b\u3068\u3093\u3069\u8d77\u304d\u306a\u3044\u304c\u3001\u80da\u53ca\u3073\u6210\u4eba\u306b\u304a\u3044\u3066\u3001\u640d\u50b7\u3084\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3078\u306e\u5fdc\u7b54\u306e\u969b\u306b\u5897\u52a0\u3057\u3001\u304c\u3093\u3084\u708e\u75c7\u7b49\u306e\u75c5\u7684\u72b6\u614b\u306b\u3088\u3063\u3066\u3082\u52a0\u901f\u3055\u308c\u308b\u3002<\/p>

\u3000HA\u306f\u3001\u4e3b\u8981\u306aHA\u53d7\u5bb9\u4f53\uff08CD44\uff09\u306b\u7d50\u5408\u3059\u308b\u5206\u5b50\u91cf\u306b\u3088\u3063\u3066\u3001\u816b\u760d\u3092\u4fc3\u9032\u307e\u305f\u306f\u6291\u5236\u3059\u308b\u52b9\u679c\u304c\u3042\u308b [12]\u3002HMW-HA\u304cCD44\u306b\u7d50\u5408\u3059\u308b\u3068\u3001\u5897\u6b96\u304c\u6e1b\u5c11\u3057\uff08CD44\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304cG1 \/ G0\u7d30\u80de\u5468\u671f\u306e\u505c\u6b62\u3092\u4fc3\u9032\uff09\u3001CD44\u306e\u816b\u760d\u6291\u5236\u7279\u6027\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u904a\u8d70\u3092\u9632\u304e\u3001\u7d30\u80de\u9593\u7d50\u5408\u3092\u5f37\u5316\u3059\u308b\u3053\u3068\u3067ECM\u306e\u900f\u904e\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u816b\u760d\u306b\u6804\u990a\u3092\u4e0e\u3048\u308b\u8840\u7ba1\u306e\u65b0\u751f\u30fb\u6210\u9577\u53ca\u3073\u816b\u760d\u7d30\u80de\u306e\u6d78\u6f64\u30fb\u79fb\u52d5\u30fb\u8ee2\u79fb\u304c\u8d77\u304d\u306b\u304f\u304f\u306a\u308a\uff08\u514d\u75ab\u5fdc\u7b54\u3068\u708e\u75c7\u3082\u6e1b\u5c11\uff09\u3001DNA\u304c\u6d3b\u6027\u9178\u7d20\u7a2e\u306b\u3088\u308a\u640d\u50b7\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304f\u306a\u308b [11]\u3002\u4e00\u65b9\u3001LMW-HA\u304cCD44\u306b\u7d50\u5408\u3059\u308b\u3068\u3001\u5168\u304f\u9006\u306e\u52b9\u679c\u304c\u3042\u308b\u3002\u4f8b\u3048\u3070\u3001\u8840\u7ba1\u7cfb\u3078\u306e\u5727\u529b\u304c\u6e1b\u5c11\u3057\u3001\u8840\u7ba1\u306e\u5d29\u58ca\u304c\u6e1b\u5c11\u3059\u308b\u305f\u3081\u3001\u8840\u7ba1\u65b0\u751f\u304c\u5897\u52a0\u3057\u3001\u85ac\u7269\u306e\u5230\u9054\u6027\u304c\u5411\u4e0a\u3059\u308b\u3068\u3044\u3046\u5229\u70b9\u304c\u3042\u308b\u3002<\/p>

2.3. \u5148\u884c\u7814\u7a76<\/strong><\/h5>

\u3000\u81b5\u7ba1\u764c\u306eTME\u306b\u304a\u3051\u308bHA\u306e\u5206\u5b50\u91cf\u306e\u8abf\u6574\u3092\u8abf\u67fb\u3057\u305f\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306f\u3001HA\u306e\u5206\u5b50\u91cf\u3092\u6e1b\u3089\u3057\u3066\u85ac\u7269\u306e\u52b9\u679c\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001\u7b2cII\u76f8\u81e8\u5e8a\u8a66\u9a13\uff08NCT01839487\uff09\u306b\u304a\u3044\u3066\u3001\u30b2\u30e0\u30b7\u30bf\u30d3\u30f3\u3068PEGPH20\uff08\u30d2\u30c8HA\u5206\u89e3\u9175\u7d20\u3092\u30dd\u30ea\u30a8\u30c1\u30ec\u30f3\u30b0\u30ea\u30b3\u30fc\u30eb\u3068\u5171\u6709\u7d50\u5408\uff09\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u6cbb\u7642\u6b74\u306e\u306a\u3044\u60a3\u8005\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u304c4.5\u30ab\u6708\uff08PEGPH20\u7121\u3057\uff09\u304b\u30898.6\u30ab\u6708\uff08PEGPH20\u6709\u308a\uff09\u306b\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f [13]\u3002\u3057\u304b\u3057\u3001\u8840\u6813\u585e\u6813\u6027\u30a4\u30d9\u30f3\u30c8\u304c\u5927\u5e45\u306b\u5897\u52a0\u3057\u305f\u305f\u3081\u3001\u8a66\u9a13\u306f\u4e2d\u65ad\u3055\u308c\u3001\u7b2cIII\u76f8\u81e8\u5e8a\u8a66\u9a13\uff08NCT02715804\uff09\u306f\u3001\u5168\u751f\u5b58\u671f\u9593\u306e\u6539\u5584\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u305f\u3081\u4e2d\u6b62\u3055\u308c\u305f [7]\u3002<\/p>

\u3000Fan\u3089\u306b\u3088\u308b\u7814\u7a76\u3067\u306f\u3001\u81b5\u7ba1\u764c\u816b\u760d\u306e\u3042\u308b\u30de\u30a6\u30b9\u306b\u5148\u305aHA\u5206\u89e3\u9175\u7d20\u3092\u6295\u4e0e\u3057\u3001\u305d\u306e\u5f8c\u306b\u5316\u5b66\u7642\u6cd5\u85ac\uff08\u30c9\u30ad\u30bd\u30eb\u30d3\u30b7\u30f3\uff09\u3092\u5857\u5e03\u3057\u305f\u5358\u5c64\u30ab\u30fc\u30dc\u30f3\u30ca\u30ce\u30c1\u30e5\u30fc\u30d6\uff08SWCNT\uff09\u3092\u6ce8\u5c04\u3057\u305f\u5834\u5408\u3001\u85ac\u5264\u306e\u5230\u9054\u6027\u3068\u6709\u52b9\u6027\u304c\u5927\u5e45\u306b\u6539\u5584\u3057\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u308b [14]\u3002HA\u5206\u89e3\u9175\u7d20\u306f\u3001\u4e00\u6642\u7684\u306b\u816b\u760d\u9593\u306e\u9593\u8cea\u5727\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u8840\u7ba1\u3092\u62e1\u5f35\u3055\u305b\u3001\u85ac\u7269\u306e\u900f\u904e\u6027\u3092\u9ad8\u3081\u308b\u52b9\u679c\u304c\u3042\u3063\u305f\u3002\u8457\u8005\u3089\u306f\u3001SWCNT\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u8840\u7ba1\u7cfb\u304c\u7de9\u304f\u30ea\u30f3\u30d1\u7cfb\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u816b\u760d\u306b\u304a\u3044\u3066\u8840\u7ba1\u900f\u904e\u6027\u53ca\u3073\u4fdd\u6301 (Enhanced Permeability and Retention, EPR) \u52b9\u679c\u304c\u5411\u4e0a\u3057\u3001\u3088\u308a\u9ad8\u6fc3\u5ea6\u306e\u85ac\u5264\u3092\u653e\u51fa\u3067\u304d\u308b\u305f\u3081\u3001\u5f93\u6765\u306e\u85ac\u5264\u3088\u308a\u3082\u512a\u308c\u305f\u6027\u80fd\u304c\u5f97\u3089\u308c\u308b\u3068\u4e3b\u5f35\u3057\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u6cbb\u7642\u6642\u306b\u4ed6\u306e\u90e8\u4f4d\u306b\u8ee2\u79fb\u3057\u305f\u53ef\u80fd\u6027\u306e\u3042\u308b\u81b5\u7ba1\u764c\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002<\/p>

3. \u63d0\u6848<\/strong><\/h5>

\u3000TME\u306bLMW-HA\u3092\u7f6e\u3044\u3066\u3001\u304c\u3093\u7d30\u80de\u304c\u816b\u760d\u3092\u4fc3\u9032\u3059\u308b\u50cd\u304d\u3092\u4fc3\u3057\u3064\u3064\u85ac\u5264\u306e\u5230\u9054\u6027\u3092\u9ad8\u3081\u3088\u3046\u3068\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u304c\u3093\u767a\u751f\u5f8c\u306e\u65e9\u3044\u3046\u3061\u306bHMW-HA\u3092\u7f6e\u304f\u3053\u3068\u3067\u304c\u3093\u7d30\u80de\u306e\u6297\u816b\u760d\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6d3b\u6027\u5316\u3059\u308c\u3070\u3001\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u3092\u53ca\u307c\u3059\u85ac\u7269\u3092\u4f7f\u7528\u305b\u305a\u306b\u304c\u3093\u3092\u6cbb\u7642\u3067\u304d\u308b\u306e\u3067\u306f\u3068\u8003\u3048\u305f\u3002\u4eba\u4f53\u306b\u304a\u3051\u308bHA\u306e\u534a\u6e1b\u671f\u304c\u77ed\u3044\uff08\u6570\u6642\u9593\u304b\u3089\u6570\u65e5\uff09 [7]\u305f\u3081\u3001\u5206\u5b50\u91cf\u3092\u3067\u304d\u308b\u3060\u3051\u9ad8\u304f\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3002<\/p>

\u30006000kDa\u3092\u8d85\u3048\u308b\u8d85\u9ad8\u5206\u5b50\u91cf\uff08vHMW\uff09HA\u306f\u3001\u304c\u3093\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u975e\u5e38\u306b\u9ad8\u304f\u3001\u6700\u9577\u5bff\u306e\u9f67\u6b6f\u985e\u3067\u3042\u308b\u30cf\u30c0\u30ab\u30c7\u30d0\u30cd\u30ba\u30df\u306b\u898b\u3089\u308c\u308b\u3002\u54fa\u4e73\u985e\u306e\u5834\u5408\u306f\u4e00\u822c\u7684\u306b\u3001\u4f53\u91cd\u304c\uff12\u500d\u306b\u306a\u308b\u3068\u5bff\u547d\u304c13\uff05\u4f38\u3073\u308b\u304c\u3001\u30cf\u30c0\u30ab\u30c7\u30d0\u30cd\u30ba\u30df\u306f\u3053\u306e\u898f\u5247\u30929\u500d\u8d85\u3048\u3001\u5bff\u547d\u306f\u6700\u592730\u5e74\u7a0b\u5ea6\u3067\u3042\u308b [10]\u3002vHMW-HA\u306f\u3001\u56fa\u6709\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u6301\u3064\u7279\u5b9a\u306e\u7a2e\u985e\u306eHAS\uff08HAS 2\uff09\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u3001HA\u5206\u89e3\u9175\u7d20\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067\u7d44\u7e54\u306b\u84c4\u7a4d\u3059\u308b\u3002HAS2\u306e\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u307e\u305f\u306fHA\u5206\u89e3\u9175\u7d20\u306e\u904e\u5270\u767a\u73fe\u306b\u3088\u308avHMW-HA\u304c\u9664\u53bb\u3055\u308c\u305f\u5834\u5408\u3001\u30cf\u30c0\u30ab\u30c7\u30d0\u30cd\u30ba\u30df\u306b\u816b\u760d\u304c\u5bb9\u6613\u306b\u767a\u75c7\u3057\u305f\u7814\u7a76\u7d50\u679c\u304b\u3089\u3001vHMW-HA\u3068\u304c\u3093\u8010\u6027\u3068\u306e\u95a2\u9023\u6027\u306f\u660e\u78ba\u306b\u793a\u3055\u308c\u3066\u3044\u308b [14]\u3002 HAS2\u306f\u30012\u3064\u306e\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u304c2\u3064\u306e\u30bb\u30ea\u30f3\u3067\u7f6e\u63db\u3055\u308c\u305f\u56fa\u6709\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u6709\u3059\u308b\u3002\u3053\u306eHAS 2\u306ecDNA\u3092\u30d2\u30c8\u80ce\u5150\u814e\u81d3\u7d30\u80de\uff08HEK 293\uff09\u3067\u904e\u5270\u767a\u73fe\u3055\u305b\u308b\u3068\u3001vHMW-HA\u3092\u751f\u6210\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b [15]\u3002\u30cf\u30c0\u30ab\u30c7\u30d0\u30cd\u30ba\u30df\u306e\u304c\u3093\u62b5\u6297\u6027\u306b\u5bc4\u4e0e\u3059\u308b\u3082\u30461\u3064\u306e\u91cd\u8981\u306a\u5074\u9762\u306f\u3001\u591a\u5c64\u3092\u5f62\u6210\u3057\u3066\u5236\u5fa1\u4e0d\u80fd\u306b\u6210\u9577\u3059\u308b\u304c\u3093\u7d30\u80de\u3068\u306f\u5bfe\u7167\u7684\u3067\u3001\u7d30\u80de\u9593\u306e\u63a5\u89e6\u5ea6\u304c\u5c11\u306a\u3044\u3046\u3061\u306b\u7d30\u80de\u304c\u5897\u6b96\u3092\u505c\u6b62\u3059\u308b\u65e9\u671f\u306e\u63a5\u89e6\u963b\u5bb3\uff08Early Contact Inhibition, ECI\uff09\u3092\u6709\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u3053\u3067\u306f\u3001\u30cf\u30c0\u30ab\u30c7\u30d0\u30cd\u30ba\u30df\u306eECI\u3092\u6a21\u5023\u3057\u3066\u81b5\u7ba1\u764c\u3092\u65e9\u671f\u306b\u767a\u898b\u3057\u3001TME\u3067LMW-HA\u3092vHMW-HA\u306b\u7f6e\u304d\u63db\u3048\u3066\u3001\u30cf\u30c0\u30ab\u30c7\u30d0\u30cd\u30ba\u30df\u306e\u3088\u3046\u306bvHMW-HA\u3092\u542b\u3080\u7d44\u7e54\u306b\u3059\u308b\u3053\u3068\u3067\u81b5\u7ba1\u764c\u3092\u6cbb\u7642\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u3092\u63d0\u793a\u3059\u308b\u3002<\/p>

3.1. \u81b5\u7ba1\u764c\u306e\u65e9\u671f\u767a\u898b<\/strong><\/h5>

\u3000\u81b5\u7ba1\u764c\u306e\u5897\u6b96\u306b\u3088\u308b\u7570\u5e38\u306a\u7d30\u80de\u5bc6\u5ea6\u306e\u65e9\u671f\u767a\u898b\u306f\u3001\u81b5\u7ba1\u7d30\u80de\u4ed8\u8fd1\u306b\u5c0f\u3055\u306a\u5727\u529b\u30bb\u30f3\u30b5\u30fc\u3092\u7f6e\u304f\u3053\u3068\u306b\u3088\u3063\u3066\u53ef\u80fd\u3068\u306a\u308b\u3002\u3053\u308c\u3089\u306e\u30bb\u30f3\u30b5\u30fc\u306f\u3001\u5185\u90e8\u306b\u6db2\u4f53\u304c\u5faa\u74b0\u53ef\u80fd\u306a\u30e1\u30c3\u30b7\u30e5\u72b6\u306e\u69cb\u9020\u7269\u306e\u5916\u9762\u306b\u8907\u6570\u4f4d\u7f6e\u3059\u308b\u3002\u3053\u306e\u69cb\u9020\u7269\u306e\u4e3b\u81b5\u7ba1\u5165\u308a\u53e3\u4ed8\u8fd1\u306b\u306f\u3001\u6cbb\u7642\u306e\u6bb5\u968e\u3067\u7d30\u80de\u57f9\u990a\u5bb9\u5668\u3068\u63a5\u7d9a\u3059\u308b\u305f\u3081\u306e\u5165\u308a\u53e3\u3068\u51fa\u53e3\u306e\u7ba1\u304c\u3042\u308b\u3002\u5727\u529b\u30bb\u30f3\u30b5\u30fc\u3068\uff12\u3064\u306e\u7ba1\u304c\u4ed8\u3044\u3066\u3044\u308b\u30e1\u30c3\u30b7\u30e5\u72b6\u306e\u69cb\u9020\u7269\u3092\u30e1\u30c3\u30b7\u30e5\u90e8\u3068\u547c\u3073\u3001\u3053\u308c\u306f\u5185\u8996\u93e1\u7b49\u3092\u7528\u3044\u3066\u4e3b\u81b5\u7ba1\u306e\u5185\u58c1\u306b\u6cbf\u3063\u3066\u5c55\u958b\u3055\u308c\u308b\u3002\u30e1\u30c3\u30b7\u30e5\u90e8\u306f\u60a3\u8005\u304c\u307e\u3060\u5065\u5eb7\u306a\u3046\u3061\u306b\u914d\u7f6e\u3055\u308c\u3001\u7d99\u7d9a\u7684\u306b\u5727\u529b\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3059\u308b\u3002\u7570\u5e38\u306a\u7d30\u80de\u5bc6\u5ea6\u304c\u691c\u51fa\u3055\u308c\u308b\u3068\u3001\u60a3\u8005\u3084\u533b\u7642\u5f93\u4e8b\u8005\u306b\u30a2\u30e9\u30fc\u30c8\u304c\u9001\u4fe1\u3055\u308c\u3001\u6cbb\u7642\u3092\u9045\u6ede\u306a\u304f\u958b\u59cb\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>

\"\"
\u56f32. \u30e1\u30c3\u30b7\u30e5\u90e8<\/div><\/div>

 <\/p>

\"\"
\u56f33. \u30e1\u30c3\u30b7\u30e5\u90e8\u304c\u81b5\u7ba1\u764c\u3092\u691c\u77e5\u3057\u305f\u69d8\u5b50<\/div><\/div>

 <\/p>

3.2. \u81b5\u7ba1\u764c\u306e\u6cbb\u7642<\/strong><\/h5>

\u3000\u6cbb\u7642\u306f\u3001\u7d30\u80de\u57f9\u990a\u5bb9\u5668\u5185\u3067vHMW-HA\u3092\u751f\u6210\u3067\u304d\u308b\u7d30\u80de\uff08HEK 293\u7b49\uff09\u3092\u57f9\u990a\u3059\u308b\u3053\u3068\u304b\u3089\u59cb\u307e\u308b\u3002\u7d30\u80de\u57f9\u990a\u5bb9\u5668\u306f\u3001\u60a3\u8005\u306e\u4e3b\u81b5\u7ba1\u5165\u308a\u53e3\u4ed8\u8fd1\u306e\u5341\u4e8c\u6307\u8178\u306e\u58c1\u306b\u57cb\u3081\u8fbc\u307e\u308c\u308b\u3002\u7d30\u80de\u57f9\u990a\u5bb9\u5668\u3092\u30e1\u30c3\u30b7\u30e5\u90e8\u306e\u5165\u308a\u53e3\u3068\u51fa\u53e3\u306e\u7ba1\u3068\u3064\u306a\u3044\u3067\u6d41\u4f53\u56de\u8def\u3092\u4f5c\u308b\u3053\u3068\u3067\u3001\u81b5\u7ba1\u764c\u7d30\u80de\u306eECM\u304b\u3089\u6db2\u4f53\u3092\u7d76\u3048\u305a\u56de\u53ce\u3057\u3066\u88dc\u5145\u3059\u308b\u3002HMW-HA\u3088\u308a\u3082LMW-HA\u3092\u591a\u304f\u542b\u3080\u3068\u4e88\u60f3\u3055\u308c\u308b\u56de\u53ce\u6db2\u306f\u3001\u7d30\u80de\u57f9\u990a\u5bb9\u5668\u306e\u4e0a\u306b\u3042\u308b\u30b2\u30eb\u6d78\u900f\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\uff08Gel Permeation Chromatography, GPC\uff09\u30d5\u30a3\u30eb\u30bf\u30fc\u306e\u5165\u53e3\u3092\u901a\u3063\u3066\u308d\u904e\u3055\u308c\u308b\u3002GPC\u30d5\u30a3\u30eb\u30bf\u30fc\u306f\u3001LMW-HA\u3092\u9078\u629e\u7684\u306b\u30d5\u30a3\u30eb\u30bf\u30fc\u3067\u9664\u53bb\u3059\u308b\u3002 \u9664\u53bb\u3055\u308c\u305fLMW-HA\u306f\u7d30\u80de\u57f9\u990a\u5bb9\u5668\u306b\u5165\u308a\u3001\u4e2d\u306e\u7d30\u80de\u304cvHMW-HA\u3092\u5408\u6210\u3059\u308b\u305f\u3081\u306e\u6804\u990a\u5206\u306b\u306a\u308b\u3002\u3053\u308c\u3089\u306f\u3001GPC\u308d\u904e\u6db2\u3068\u5171\u306b\u3001\u30e1\u30c3\u30b7\u30e5\u90e8\u306b\u6d41\u308c\u3001\u81b5\u7ba1\u764c\u7d30\u80de\u306eECM\u306b\u5c4a\u3051\u3089\u308c\u308b\u3002\u3088\u3063\u3066TME\u3067\u306f\u3001LMW-HA\u304c\u6e1b\u5c11\u3057\u3001vHMW-HA\u304c\u5897\u52a0\u3059\u308b\u3002\u5f93\u3063\u3066\u81b5\u7ba1\u764c\u7d30\u80de\u8868\u9762\u3067\u306eCD44\u3068\u306e\u7d50\u5408\u306fvHMW-HA\u3084HMW-HA\u304cLMW-HA\u306b\u6253\u3061\u52dd\u3061\u3001\u7d30\u80de\u5185\u816b\u760d\u6291\u5236\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3084\u305d\u306e\u4ed6\u306e\u7d30\u80de\u56fa\u6709\u306e\u6297\u816b\u760d\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/p>

\u3000\u30e1\u30c3\u30b7\u30e5\u90e8\u304c\u81b5\u81d3\u306e\u5916\u5074\u306b\u3042\u308b\u30ea\u30f3\u30d1\u7bc0\u3088\u308a\u3082\u4e3b\u81b5\u7ba1\u306b\u8fd1\u3044\u4f4d\u7f6e\u306b\u3042\u308b\u305f\u3081\u3001\u81b5\u7ba1\u764c\u7d30\u80de\u306eECM\u304b\u3089LMW-HA\u3092\u6392\u51fa\u3067\u304d\u308b\u3002\u307e\u305f\u3001\u672c\u624b\u6cd5\u306f\u3001\u81b5\u81d3\u306e\u5916\u5074\u304b\u3089\u30a2\u30d7\u30ed\u30fc\u30c1\u3059\u308b\u8840\u7ba1\u3092\u4ecb\u3057\u3066\u9001\u9054\u3055\u308c\u308b\u5316\u5b66\u7642\u6cd5\u3088\u308a\u3082\u76f4\u63a5\u7684\u306b\u81b5\u7ba1\u7d30\u80de\u306b\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>

\"\"
\u56f34. \u6cbb\u7642\u6642\u306e\u69d8\u5b50<\/div><\/div>

 <\/p>

\"\"
\u56f35. \u81b5\u81d3\u306e\u8840\u7ba1\u7cfb\u3068\u30ea\u30f3\u30d1\u7cfb\u306e\u4f4d\u7f6e\u95a2\u4fc2 [16]<\/div><\/div>

 <\/p>

4. \u8ab2\u984c\u3068\u5c55\u671b<\/strong><\/h5>

\u3000\u672c\u7814\u7a76\u3067\u306f\u81b5\u7ba1\u764c\u3092\u6cbb\u7642\u3059\u308b\u65b9\u6cd5\u3092\u793a\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u985e\u4f3c\u306e\u304c\u3093\u7a2e\u306b\u540c\u3058\u3088\u3046\u306b\u9069\u7528\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u306b\u7559\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u4f8b\u3048\u3070\u3001\u5206\u5b50\u91cf400\u301c600kDa\u306e\u81b5\u7ba1\u764c\u7d30\u80de\u30b3\u30ed\u30cb\u30fc\u3067\u6210\u9577\u3068\u904a\u8d70\u304c\u898b\u3089\u308c\u305f\u306e\u306b\u5bfe\u3057 [9]\u3001\u4e73\u764c\u7d30\u80de\u306f\u306f\u308b\u304b\u306b\u4f4e\u3044117kDa\u3067\u904a\u8d70\u306e\u6e1b\u5c11\u3092\u793a\u3057\u305f [8]\u3002\u3053\u308c\u306f\u3001\u672c\u624b\u6cd5\u3092\u5168\u8eab\u306b\u9069\u7528\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u305a\u3001\u5404\u7a2e\u306e\u304c\u3093\u306b\u5fdc\u3058\u3066\u95be\u5024\u3092\u8abf\u6574\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3002<\/p>

\u3000\u30b3\u30f3\u30bb\u30d7\u30c8\u3092\u5b9f\u73fe\u3059\u308b\u4e0a\u3067\u306e1\u3064\u306e\u61f8\u5ff5\u70b9\u306f\u3001\u975e\u5e38\u306b\u5c0f\u3055\u3044\u5bf8\u6cd5\u304c\u5fc5\u8981\u306a\u3053\u3068\u3067\u3042\u308b\u3002\u4f8b\u3048\u3070\u3001\u5727\u529b\u30bb\u30f3\u30b5\u30fc\u304c\u30e1\u30c3\u30b7\u30e5\u72b6\u306e\u69cb\u9020\u7269\u306e\u5916\u9762\u306b\u4f4d\u7f6e\u3059\u308b\u306b\u306f\u3001\u4e3b\u81b5\u7ba1\u306e\u5185\u5468\u3088\u308a\u3082\u5927\u5e45\u306b\u5c0f\u3055\u304f\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002\u6700\u8fd1\u3067\u306f\u3001\u30bb\u30f3\u30b5\u30fc\u306e\u5c0f\u578b\u5316\u304c\u9032\u3093\u3067\u304a\u308a\u3001\u6a19\u6e96\u7684\u306a\u76ae\u4e0b\u6ce8\u5c04\u91dd\u3067\u6ce8\u5c04\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b [17] \u3002\u3053\u308c\u306f\u4f53\u6e29\u6e2c\u5b9a\u7528\u306e\u30bb\u30f3\u30b5\u30fc\u3060\u304c\u3001\u5727\u529b\u30bb\u30f3\u30b5\u30fc\u3082\u8fd1\u3044\u672a\u6765\u306b\u540c\u69d8\u306e\u5927\u304d\u3055\u3067\u88fd\u9020\u53ef\u80fd\u306b\u306a\u308b\u3068\u63a8\u6e2c\u3055\u308c\u308b\u3002<\/p>

5. \u7d50\u8ad6<\/strong><\/h5>

\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u5727\u529b\u30bb\u30f3\u30b5\u30fc\u3068\u6d41\u4f53\u56de\u8def\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u305d\u308c\u305e\u308c\u3001\u30cf\u30c0\u30ab\u30c7\u30d0\u30cd\u30ba\u30df\u306e\u65e9\u671f\u63a5\u89e6\u963b\u5bb3\u3068\u8d85\u9ad8\u5206\u5b50\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306e\u751f\u6210\u80fd\u529b\u3092\u6a21\u5023\u3059\u308b\u3053\u3068\u3067\u3001\u6d78\u6f64\u6027\u81b5\u7ba1\u764c\u306e\u65e9\u671f\u767a\u898b\u3068\u6cbb\u7642\u306b\u3064\u306a\u3052\u308b\u305f\u3081\u306e\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u3092\u63d0\u793a\u3057\u305f\u3002\u672c\u63d0\u6848\u304c\u3001\u73fe\u5728\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3001\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u3092\u53ca\u307c\u3059\u5316\u5b66\u7642\u6cd5\u3068\u306f\u5225\u306e\u6709\u52b9\u306a\u9078\u629e\u80a2\u3068\u306a\u308b\u3053\u3068\u3092\u671b\u3080\u3002<\/p>

6. \u53c2\u8003\u6587\u732e<\/strong><\/h5>

[1] \u771e\u5cf6\u559c\u5e78: \u81b5\u81d3\u304c\u3093\u751f\u5b58\u7387\u5411\u4e0a\u306e\u305f\u3081\u306e\u65bd\u7b56\u3078\u306e\u8981\u671b\u66f8, 2021<\/p>

[2] Orth, M., Metzger, P., Gerum, S. et al. (2019). Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches. Radiation Oncology 14, 141.<\/p>

[3] Stark, A., Eibl, G. (2015). Pancreatic Ductal Adenocarcinoma. Pancreapedia: Exocrine Pancreas Knowledge Base.<\/p>

[4] https:\/\/www.ncc.go.jp\/jp\/ncce\/clinic\/hepatobiliary_and_pancreatic_surgery\/050\/3\/20171102124510.html<\/a>\u3000\uff082022\u5e747\u67088\u65e5\uff09<\/p>

[5] https:\/\/www.bumrungrad.com\/en\/health-blog\/june-2022\/endoscopic-advances-for-pancreatic-cancer<\/a>\uff082022\u5e746\u670823\u65e5\uff09<\/p>

[6] Sarantis, P., Koustas, E., Papadimitropoulou, A., Papavassiliou, A. G., & Karamouzis, M. V. (2020). Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy. World journal of gastrointestinal oncology, 12(2), 173\u2013181.<\/p>

[7] Principe, D. R., Underwood, P. W., Korc, M., Trevino, J. G., Munshi, H. G., & Rana, A. (2021). The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy. Frontiers in oncology, 11, 688377.<\/p>

[8]\u00a0Tavianatou, A. G., Caon, I., Franchi, M., Piperigkou, Z., Galesso, D., & Karamanos, N. K. (2019). Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer. The FEBS journal, 286(15), 2883\u20132908.<\/p>

[9] Sato, N., Kohi, S., Hirata, K., & Goggins, M. (2016). Role of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlight. Cancer Science, 107(5), 569-575.<\/p>

[10] Bohaumilitzky, L., Huber, A., Stork, E., Wengert, S., Woelfl, F., Boehm, H. (2017). A Trickster in Disguise: Hyaluronan’s Ambivalent Roles in the Matrix. Frontiers in oncology vol. 7 242.<\/p>

[11] Liu, M., Tolg, C., & Turley, E. (2019). Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment. Frontiers in immunology, 10, 947.<\/p>

[12] Takasugi, M., Firsanov, D., Tombline, G., Ning, H., Ablaeva, J., Seluanov, A., Gorbunova, V. (2020). Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. Nature Communications 11, 2376.<\/p>

[13] https:\/\/www.cancertherapyadvisor.com\/home\/cancer-topics\/pancreatic-cancer\/pegph20-may-improve-pfs-in-pancreatic-cancer\/<\/a>\u3000\uff082022\u5e746\u670819\u65e5\uff09<\/p>

[14] Fan, Y. F., Shang, W. T., Lu, G. H., Guo, K. X., Deng, H., Zhu, X. H., Wang, C. C., & Tian, J. (2021). Decreasing hyaluronic acid combined with drug-loaded nanoprobes improve the delivery and efficacy of chemotherapeutic drugs for pancreatic cancer. Cancer letters, 523, 1\u20139.<\/p>

[15] Tian, X., Azpurua, J., Hine, C., Vaidya, A., Myakishev-Rempel, M., Ablaeva, J., Mao, Z., Nevo, E., Gorbunova, V., & Seluanov, A. (2013). High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature, 499(7458), 346\u2013349.<\/p>

[16] Tummers, W. S., Miller, S. E., Teraphongphom, N. T., van den Berg, N. S., Hasan, A., Longacre, T. A., Fisher, G. A., Bonsing, B. A., Vahrmeijer, A. L., Gambhir, S. S., Swijnenburg, R. J., Rosenthal, E. L., & Poultsides, G. A. (2019). Detection of visually occult metastatic lymph nodes using molecularly targeted fluorescent imaging during surgical resection of pancreatic cancer. HPB, 21(7), 883\u2013890.<\/p>

[17] Shi, C., Andino-Pavlovsky, V., Lee, S. A., Costa, T., Elloian, J., Konofagou, E. E., & Shepard, K. L. (2021). Application of a sub-0.1-mm3 implantable mote for in vivo real-time wireless temperature sensing. Science advances, 7(19).<\/p>

 <\/p>

<\/div>
\u00a0<\/div>
\"\"<\/div><\/div>
\u9234\u6728 \u7f8e\u5229\u4e9c\uff08\u3059\u305a\u304d \u307f\u308a\u3042\uff09<\/strong><\/h5>
\u30c6\u30eb\u30e2\u682a\u5f0f\u4f1a\u793e R&D\u30a8\u30f3\u30b8\u30cb\u30a2\u3000<\/strong><\/div>
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