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    Tokyo Women’s Medical University Global COE (Centers of Excellence);
    Multidisciplinary Education and Research Center for the Establishment of Regenerative Medicine

    Institute of Advanced Biomedical Engineering and Science
    Tokyo Women’s Medical University
    8-1 Kawada-cho, Shinjuku-ku
    Tokyo 162-8666 JAPAN

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The Objective of Establishing a Center

This program will establish an education and research center that will actively promote partnerships between medicine and engineering, and between academia and industry. At the same time, it will foster clinicians who will implement the next generation of advanced medicine, as well as the researchers who will further develop the healthcare industry, an area that promises to take on increasing importance in the future.

Specifically, the aim is to establish a multidisciplinary education and research center that fosters personnel who can develop and implement the next generation of advanced treatments, especially regenerative medicine. These therapies are expected to enable curative treatments that go significantly beyond the limits of conventional drug therapy focused on symptomatic treatment, or surgical therapies, typified by procedures such as removal of cancers.
The highly-regarded Center for Tissue Engineering and Regenerative Medicine was adopted by the 21st Century COE Program, and we will strive to develop it further as an education and research center.

We aim to develop personnel who can implement leading edge medical treatment in the following three areas which we believe will play a central role in ten years’ time:

   1.Regenerative medicine

   2.Medical transplantation with immunological tolerance

   3.Genetic medicine.

In the field of regenerative medicine, we have already successfully used cultured cell sheet transplants prepared using a temperature-responsive culture dish developed by the TWMU Institute of Advanced Biomedical Engineering and Science. Clinical applications have included treatment of skin (severe burns and treatment of scars), the cornea (limbal stem cell deficiency), the heart (dilated cardiomyopathy), and the esophagus (esophageal stenosis after endoscopic resection of epithelial cancer of the mucous membrane). In addition, clinical studies with the periodontal membrane, lung, liver and so on are being prepared. Looking ahead ten years, we aim to achieve next generation regenerative medicine combining immunological tolerance and gene therapy. This kind of R&D is not limited to medical science practitioners. Rather, it calls for new kinds of researchers who can carry out multidisciplinary R&D that combines a broad range of academic fields including applied chemistry, bioethics, and regulatory science, encompassing molecular biology, stem cell biology, biomedicine, pharmaceutical sciences, and bioreactor development.
The development of this kind of personnel involves providing a place where science, engineering and pharmacology researchers can engage with medical science researchers under the same roof, working together on shared goals without regard for cultural or linguistic barriers. In addition to classroom lectures and practical work, specific and multidisciplinary research activities are also essential. Furthermore, we want to produce doctors who also have the ability to plan and carry out large-scale, multicenter clinical trials

In the current state of medical research in Japan, while the number of articles published in top-class basic science journals like Nature, Science, and Cell, is on a par with Europe and America, Japan lags far behind Europe and America in contributions to the New England Journal of Medicine, Lancet, JAMA and similar prestigious clinical journals. Therefore it is our goal to further develop Japan’s world-class basic medical research, while contributing to promoting the health of the Japanese public and fostering the healthcare industry.